Liquid Biopsy to Characterize Cell-Free DNA in Cancer Detection and Monitoring

  • Nguyễn Ngọc Trân Department of Computational Biomedicine, Vingroup Big Data Institute, Hanoi
Keywords: Cell-free DNA, liquid biopsy, cancer detection


Liquid biopsy, a concept introduced approximately a decade ago, refers to noninvasive approaches that have become the focus of biomedical research. In clinical oncology and research, the term liquid biopsy is used in a broad sense as the sampling and analysis of analytes including cell-free DNA from various accessible biological fluids for diagnosis, prognosis and prediction of a therapeutic response. This technology has the potential to be used in tracking the genomic evolution of tumors over time. It may also have therapeutic implications in terms of its ability to detect actionable events or resistant subclonal populations while avoiding the need to conduct repeated biopsies. This paper briefly reviews the major advances in liquid biopsy assay technologies and discusses the types of cancers that most likely benefit from early detection.

Author Biography

Nguyễn Ngọc Trân, Department of Computational Biomedicine, Vingroup Big Data Institute, Hanoi

Nguyen Ngoc Tran was born in Ho Chi Minh City in 1989. She received the Bachelor in Pharmacy from The University of Medicine and Pharmacy in Ho Chi Minh City, Ho Chi Minh, Vietnam in 2011. She went on to receive a Ph.D. in Cancer Biology from The University of Texas at MD Anderson Cancer Center, Houston, Texas in 2018. Her thesis work focused on studying the mechanism of skin cancer development. She spent two years working at Moffitt Cancer Center, Tampa, Florida as a Research Associate and Postdoctoral Scholar. Since 2019, she has been with Vingroup Big Data Institute, Hanoi, Vietnam, where she is currently a Research Scientist. Her main area of research interest is translational research, including identifying preventative biomarkers and developing diagnostic tests for cancer. Dr. Nguyen Ngoc Tran is a member of the American Association for Cancer Research.

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